The three-way refrigeration system consists of a cascade condenser between the refrigerant systems using R410A 404A refrigerant for 1st and 2nd layer compression, 2nd layer R-13, 3rd layer R-14, and 3rd stage refrigerant. By constructing a three-way freezing system, the temperature of the cryogenic temperature is -100°C. The 3-way cryogenic system unit can control the recovery of organic solvents from the reactionary or the heat generated by the cooler.